INVESTIGATION ON THE EFFECT OF VARIOUS RADIATION QUALITIES AND RADIATION DOSES ON THE SERUM ALBUMIN AND BLOOD PICTURE OF RATS

Journal Article · Thu Dec 01 04:00:00 EST 1960 · Strahlentherapie (West Germany)

OSTI ID:4105846

Peters, K; Bauer, R

The examination of the action of various doses and qualities of radiation showed in part, from the survival rates and relative organ weights, significant differences between dose and dose, and similarly between radiation quality and radiation quality. The dynamics of the changes in the serum albumen during the elapse of 38 days p.r. showed for the animals dying during the time of experimentation broadly the already described picture of decrease in albumin and globulin, which arises after irradiation. On the other hand the changes in the serum albumen of the surviving animals was not measured with this scheme. Two cases of hyperalbuminemia, one of which was corrplated with hypergammaglobulinemia, were emphasized. The initial increase in the albumin values on the 1/sup st/ and 4/sup th/ day p.r. were interpreted as mobilized deposited albumin. A corresponding, but less intense increase in the alpha - globulin on the 1/sup st/ day p.r. could also be interpreted as released deposits, or as compensatory resistance reactions of the organism, following the adaptation syndrome after Selye. The total picture of the measured changes in the serum protein after radiation allows a dysproteinemia to be recognized which is far more complex than was already supposed. By means of single examples and group values the importance of the final situation for the survival of the radiation insult was pointed out. Decreased albumins, raised helial phagocyt and alpha globulins as well as increased leucocyte count at the time of radiation offers a favorable survival prognosis. The relation between the protein values of serum and the corpuscular hemogram values was discussed. It can be deduced from the sum of the present findings that after whole-body radiation of rats the dysproteinemia and the disregulation of the regenerative courses of reaction after radiation with electrons in the examined dose area, are unambiguously slighter than after the radiation with ultrahard x rays or x radiation from 200 kv. (auth)

• Research Organization: Universitat, Tubingen, Ger.
• NSA Number: NSA-15-008566
• OSTI ID: 4105846
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 113; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ALBUMINS
BIOLOGY AND MEDICINE
BLOOD SERUM
ELECTRONS
LIFETIME
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RATS
X RADIATION