FURTHER RESULTS ABOUT THE RADIATION PROTECTIVE EFFECT OF STEROID HORMONES

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Radiobiol. Radiotherap.

OSTI ID:4640077

Baudisch, E; Seyfarth, Vetterlein

Adrenocortico hormone (ACTH) and the extract of the adrenal cortex increased the rate of survival of rats irradiated with 650 r x radiation over the whole body. The number of the surviving animals was doubled when conrpared to the control group. When using young animals and older or emaciated rats, an effect of protection could not be proved. Those animals died even earlier. The death of the animals of the control group did not continually result during the time of observation of 30 days, but it resulted with three summit points. The protective effect showed especially in a diminishing of the second maximum of dying at the end of the second week after irradiation but came also to the expression at the beginning of the fourth week, the third summit point. It is evident that male rats are more sensitive to x rays than female ones. The weight curves show a retarded decrease of weight after treatment with ACTH and cortineurin in the first week and in the third week an increase opposite to a weight decrease of the control animals. Increase of weight is valued as a prognostically favorable token. Male rats show a higher loss of weight besides the increased x-ray sensitivity and stronger changes of serum protein. The radioinduced dysproteinemia is strengthened by ACTH and cortineurin. Albumin and gamma globulin reduction brings about the death of the animals. The different results in the protection tests with ACTH and adrenal-cortex hormone are attributed partly to the different mixing of the animal material without paying attention to the different sensitivity of male and female animals. The common state and the age as well as the radiation and hormone dose and the time of the hormone application also play an important part in results. (auth)

• Research Organization: Friedrich-Schiller-Universitat, Jena, Ger.
• NSA Number: NSA-17-035556
• OSTI ID: 4640077
• Journal Information: Radiobiol. Radiotherap., Journal Name: Radiobiol. Radiotherap. Vol. Vol: 4
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ACTH
ADRENAL GLANDS
AGE
ALBUMINS
BIOLOGY AND MEDICINE
BLOOD SERUM
BODY
CORTICOSTEROIDS
GLOBULINS
HORMONES
PROTEINS
RADIATION PROTECTION
RADIOSENSITIVITY
RATS
SEX
STEROIDS
SURVIVAL TIME
TISSUE EXTRACTS
X RADIATION