Ninety-day study of inhaled 1,3,5-trichloro-2,4,6-trinitrobenzene in rats

Technical Report · Fri May 28 04:00:00 EDT 1982

OSTI ID:5293661

Johnson, J S

Male and female rats were exposed to 2, 10, and 20 mg/m/sup 3/ of 1,3,5-Trichloro-2,4,6-Trinitrobenzene (TCTNB) dust for six hrs daily, five days a week, for up to 13 weeks. After 13 weeks of exposure, animals were sacrificed and examined for changes in blood constituents, internal organs, and tissues resulting from TCTNB exposure. Mortality at the high dose level was 37%, with deaths occurring in weeks 1-6. There was no mortality in either the middle-level or low-level exposure groups. In all decedents, signs of respiratory distress were observed in the days before death, and marked pathologic changes in the lung were observed at necropsy. Some pulmonary disease was observed in animals sacrificed at four weeks and, to a lesser extent, in those surviving to the scheduled 13-week sacrifice. Small increases in total erythrocyte counts and hematocrit were observed at four and 13 weeks in treated animals, but no other appreciable hematologic changes were apparent. Weekly body weights remained unaffected by TCTNB exposure. Additional groups of male and female rats were exposed once for six hrs and subsequently challenged twice to see if the mode of death was related to sensitization to TCTNB, but no deaths occurred.

• Research Organization: Lawrence Livermore National Lab., CA (USA)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 5293661
• Report Number(s): UCRL-15469; ON: DE82017296
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD CHEMISTRY
BLOOD COUNT
BODY
BODY FLUIDS
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
DUSTS
ERYTHROCYTES
EXPOSURE CHAMBERS
HYDROCARBONS
INHALATION
INTAKE
MAMMALS
MATERIALS
MORTALITY
NITRO COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUES
TOXICITY
VERTEBRATES