Model for the $sup 224$Ra-protraction effect

Technical Report · Wed Jan 01 00:00:00 EST 1975

DOI:https://doi.org/10.2172/4088540· OSTI ID:4088540

Groer, P G; Marshall, J H

It was pointed out that for a fixed total dose the observed incidence of bone sarcomas in German children and adults exposed to $sup 224$Ra was higher the lower the dose rate. Two mathematical models that exhibit a protraction effect are presented in this report. Both models replace cells killed by $alpha$ radiation with normal endosteal cells. This regeneration of cells increases the total number of cells at risk and leads thus to the production of more tumor cells during the longer time periods corresponding to the lower dose rates. (auth)

• Research Organization: Argonne National Lab., Ill. (USA)
• NSA Number: NSA-33-020541
• OSTI ID: 4088540
• Report Number(s): ANL-75-60(Pt.2)
• Resource Relation: Other Information: Orig. Receipt Date: 30-JUN-76; Related Information: Radiological and Environmental Research Division annual report, July 1974-- June 1975
• Country of Publication: United States
• Language: English

Related Subjects

N48610* -Life Sciences-Radionuclide Effects (Internal Source)-Man
560161* -Biomedical Sciences
Applied Studies- Radiation Effects-Radionuclide Effects-Internal Source-Man
*ANIMAL CELLS- BIOLOGICAL REGENERATION
*BIOLOGICAL RADIATION EFFECTS- MATHEMATICAL MODELS
*BONE TISSUES- RADIATION DOSES
*OSTEOSARCOMAS- RADIOINDUCTION
ALPHA PARTICLES
CHILDREN
DOSE RATES
MAN
RADIUM 224