Model for the $sup 224$Ra-protraction effect

Technical Report · Tue Dec 31 23:00:00 EST 1974

DOI:https://doi.org/10.2172/4088540· OSTI ID:4088540

Groer, P G; Marshall, J H

It was pointed out that for a fixed total dose the observed incidence of bone sarcomas in German children and adults exposed to $sup 224$Ra was higher the lower the dose rate. Two mathematical models that exhibit a protraction effect are presented in this report. Both models replace cells killed by $alpha$ radiation with normal endosteal cells. This regeneration of cells increases the total number of cells at risk and leads thus to the production of more tumor cells during the longer time periods corresponding to the lower dose rates. (auth)

• Research Organization: Argonne National Lab., Ill. (USA)
• NSA Number: NSA-33-020541
• OSTI ID: 4088540
• Report Number(s): ANL--75-60(Pt.2)
• Country of Publication: United States
• Language: English

Related Subjects

*ANIMAL CELLS-- BIOLOGICAL REGENERATION
*BIOLOGICAL RADIATION EFFECTS-- MATHEMATICAL MODELS
*BONE TISSUES-- RADIATION DOSES
*OSTEOSARCOMAS-- RADIOINDUCTION
560161* --Biomedical Sciences
Applied Studies-- Radiation Effects--Radionuclide Effects--Internal Source--Man
ALPHA PARTICLES
CHILDREN
DOSE RATES
MAN
N48610* --Life Sciences--Radionuclide Effects (Internal Source)--Man
RADIUM 224