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Osteosarcomogenic effectiveness of the short-lived /sup 224/Ra compared with that of the long-lived /sup 226/Ra in mice

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574601· OSTI ID:7310787
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/sup 224/Ra was applied with one single injection or with repeated injections (twice weekly over various time periods, up to 36 weeks). In general the bone tumor incidence increased with dose but with the restriction that the maximum instantaneous dose rate be not too high. The 1080-rad total skeletal dose thus resulted in a bone tumor incidence between 15 and 90% depending on the length of the injection spans. These results were compared with the effect of singly injected long-lived /sup 226/Ra, using data by M. Finkel et al. (1). It was observed that the specific bone tumor production by /sup 226/Ra, expressed as incidence per unit of total accumulated skeletal dose, was steadily diminished with an increase of the dose. As a consequence, we found that mice after a single injection of the long-lived /sup 226/Ra within the tested dose range had in general a considerably lower bone tumor incidence than those mice having received comparable skeletal doses through repeated injections of the short-lived /sup 224/Ra over a longer period.

Research Organization:
Institut fuer Biologie der Gesellschaft fuer Strahlen- und Umweltforschung mbH, Neuherberg, Ger.
OSTI ID:
7310787
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 70:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE RATES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
ISOTOPES
MAMMALS
MICE
NEOPLASMS
NUCLEI
OSTEOSARCOMAS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIUM 224
RADIUM 226
RADIUM ISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES