Toxicity of sup 241 Am in male C57BL mice: relative risk versus sup 226 Ra

Journal Article · Wed May 01 00:00:00 EDT 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577818· OSTI ID:5543451

Schoeters, G E; Maisin, J R; Vanderborght, O L ^[1]

---

1. Department of Radioprotection, S.C.K./C.E.N., Mol, (Belgium)

A life-span study on male C57BL mice after injection of various doses of{sup 241}Am was conducted. The effects on life span were evaluated and the incidence of tumors was determined by procedures that take competing risks into account. Bone tumors were induced in the mice by injections of 22 and 58 Bq {sup 241}Am per g. The mice died early from nonneoplastic diseases at the higher dose levels (190, 373, and 1197 Bq {sup 241}Am/g). Additionally, spontaneously occurring tumors such as liver carcinomas, lymphosarcomas, and lymphoreticulosarcomas occurred at an enhanced rate with increasing dose level. The data for survival time after {sup 241}Am injection and death with bone tumor were compared to data collected previously for {sup 226}Ra-injected mice of the same C57BL strain. This enabled direct comparison in the same strain of the effects of the bone-surface seeker {sup 241}Am to the effects of the bone-volume seeker {sup 226}Ra. The proportional hazards model was applied and the rate of death with bone tumor was 12.9 +/- 5.2 times higher after {sup 241}Am injection than after {sup 226}Ra injection if the regression covariate was the average dose to the skeleton. The relative risk was 3.5 +/- 1.7 if regressed on the injected radioactivity. The mortality rate after {sup 241}Am injection was 20.4 +/- 3.6 times higher than after {sup 226}Ra injection if regressed on average dose to the skeleton.

• OSTI ID: 5543451
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 126:2; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
AMERICIUM 242
AMERICIUM ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBON 14 DECAY RADIOISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION
ISOTOPES
LIFE SPAN
MAMMALS
MICE
NEOPLASMS
NUCLEI
ORGANS
RADIATION DOSES
RADIOINDUCTION
RADIOISOTOPES
RADIUM 226
RADIUM ISOTOPES
RISK ASSESSMENT
RODENTS
SKELETON
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES