Comparative toxicity of /sup 226/Ra, /sup 239/Pu, /sup 241/Am, /sup 249/Cf, and /sup 252/Cf in C57BL/Do black and albino mice

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576102· OSTI ID:5577780

Taylor, G N; Mays, C W; Lloyd, R D; Gardner, P A; TAlbot, L R; McFarland, S S; Pollard, T A; Atherton, D R; vanMoorhem, D; Brammer, D

Groups of C57BL/Do (black and albino) mice were injected with graded activities of /sup 226/Ra, /sup 239/Pu, /sup 241/Am, /sup 249/Cf, or /sup 252/Cf and were followed throughout life. Bone sarcoma was the principal radiation-induced end point, and the risks associated with average skeletal doses of the four transuranium radionuclides, relative to radium, were determined. The relative biological effectiveness (RBE) was calculated for each emitter by dividing its risk coefficient (bone sarcomas per 10/sup 6/ mouse-rad) by the risk coefficient for /sup 226/Ra. Combined data for males and females in both black and albino mice gave the following values +- SD for the RBE relative to /sup 226/Ra = 1.0: /sup 239/Pu = 15.3 +- 3.9, /sup 241/Am = 4.9 +- 1.4, /sup 249/Cf = 5.0 +- 1.4, and /sup 252/Cf = 2.6 +- 0.8. About 70% of the tumors occurred in the axial skeleton, and the risk coefficient for females averaged about four times higher than for males when all five nuclides were included. The RBE of fission fragment irradiation from /sup 252/Cf for cancer induction, relative to ..cap alpha.. irradiation, for the combined data in all of the animals given /sup 252/Cf and /sup 249/Cf, was 0.02 +- 0.28, in agreement with the calculated theoretical value of 0.03, based on the ratio of summed track lengths in tissue.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City
• DOE Contract Number: AC02-76EV00119
• OSTI ID: 5577780
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 95:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

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560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 249
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CHARGED PARTICLES
DATA
DELAYED RADIATION EFFECTS
DISEASES
DOSIMETRY
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FERMIONS
FISSION NEUTRONS
FUNCTIONS
HADRONS
HEAVY NUCLEI
INFORMATION
ISOTOPES
MAMMALS
MICE
NEOPLASMS
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OSTEOSARCOMAS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIUM 226
RADIUM ISOTOPES
RBE
RETENTION FUNCTIONS
RODENTS
SARCOMAS
SKELETAL DISEASES
SKELETON
VERTEBRATES
YEARS LIVING RADIOISOTOPES