Bone tumor location in dogs given skeletal irradiation by {sup 239}Pu or {sup 226}Ra

Journal Article · Wed Oct 01 04:00:00 EDT 1997 · Health Physics

DOI:https://doi.org/10.1097/00004032-199710000-00015· OSTI ID:589118

Lloyd, R D; Taylor, G N; Miller, S C ^[1]

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1. Univ. of Utah, Salt Lake City, UT (United States); and others

Statistical analyses have indicated that there was a significant difference between dogs injected with bone volume-seeking {sup 226} Ra as compared to those given bone surface-seeking {sup 239}Pu with respect to location within the skeleton of 334 radiation-induced primary bone malignancies. Corresponding differences also were event when dogs given bone volume-seeking {sup 90}Sr or bone surface-seeking {sup 241}Am, {sup 228}Th {sup 248,252}Cf, or {sup 224}Ra (which decays mostly on bone surfaces because of its short, 3.6 d half time) were included along with the {sup 226}Ra or {sup 239}Pu, respectively (562 total tumors). Further analysis suggested that higher values of percent red marrow (M) and bone turnover rate (R) are correlated with increased probability. of tumor appearance at a particular location within the skeleton for the surface seekers. Proportionately higher values of M and R are associated with skeletal sites containing mostly trabecular bone as compared to those with mostly compact (cortical) bone. Coefficients of determination (r{sup 2}) for the relationship between percent of total tumors vs the combination of percent red marrow and turnover rate (= MR) was about 0.7 for the surface seekers but only about 0.1 for the volume seekers. This indicates that the neoplastic effects of surface seekers, but not volume seekers, are associated with the presence of trabecular bone at the various sites of radio nuclide deposition within the skeleton. 10 refs., 3 tabs.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 589118
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 4 Vol. 73; ISSN HLTPAO; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BONE SEEKERS
DOGS
INJECTION
NEOPLASMS
PLUTONIUM 239
PROBABILITY
RADIATION DOSES
RADIOINDUCTION
RADIOSENSITIVITY
RADIUM 226
RBE
SKELETON
TRABECULAR BONE