Model for the induction of bone cancer by /sup 224/Ra. [In man]

Conference · Thu Jan 01 00:00:00 EST 1976

OSTI ID:7319458

Groer, P G; Marshall, J H

A mathematical model for the transformation of normal endosteal cells into malignant tumor cells by ..cap alpha.. irradiation is applied to /sup 224/Ra. The model postulates that a normal endosteal cell near the bone surface is transformed into a malignant cell by three consecutive events. The first two events are the initiation events. The probability of their occurrence is proportional to the absorbed endosteal dose and they generate dormant tumor cells. These dormant tumor cells are promoted by the third event, the promotion event. The probability of this last event is proportional to the rate of bone remodeling but independent of the radiation dose. In competition with these transforming events is the killing of any endosteal cell by ..cap alpha.. irradiation. Killing is balanced by replacement of killed endosteal cells by normal stem cells. This model provides the following interesting predictions for the human /sup 224/Ra cases: after the decay of /sup 224/Ra the tumor rate decreases exponentially at a rate proportional to the bone turnover rate; for exposure to the same dose the model predicts an increased number of tumors for protracted exposure (i.e., exposure at a lower dose rate). Implications of this model for the therapy of ankylosing spondylitis are discussed. Statistical procedures are suggested for comparison of this theoretical model with the existing data on the induction of osteosarcomas by /sup 224/Ra in man.

• Research Organization: Argonne National Lab., IL (USA)
• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 7319458
• Report Number(s): CONF-760992-17; TRN: 77-014744
• Resource Relation: Conference: 2. international symposium on biological effects of Ra-224, Neuherberg/Muenchen, F.R. Germany, 20 Sep 1976
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE TISSUES
PATHOLOGICAL CHANGES
MAN
BIOLOGICAL RADIATION EFFECTS
OSTEOSARCOMAS
RADIOINDUCTION
RADIUM 224
BIOLOGICAL MODELS
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
INTERNAL IRRADIATION
MATHEMATICAL MODELS
NEOPLASMS
TIME DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
PATHOGENESIS
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
RADIUM ISOTOPES
SARCOMAS
SKELETAL DISEASES
TISSUES
VERTEBRATES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man