RADIOPROTECTIVE ACTION OF SODIUM $gamma$-HYDROXYBUTYRATE (in French)
Journal Article
·
· Agressologie (France)
OSTI ID:4087008
The pharmacology of 4-hydroxybutyrate is briefly reviewed. The present study was carried out with female mice; 1 g/kg 4-hydroxybutyrate was injected intraperitoneally in a dose of 0.5 rttl cortaining nine parts of the Na salt per 1,000, in most cases 1/2 to 1 hr before irradiation. LD/sub 100/ for control aniraals was about 875 r; for those treated with 4-hydroxybutyrate, about 1100 r, both at 30 days. LD/sub 50/ at 30 days was 750 r and 900 r respectively. The first set of figures is tentative. A similar dose given three hr before irradiation or immediately after irradiation does not appear to diminish mortality. The drug induces narcosis at this level. A dose of 250 mg/kg prevents the latter effect, but the radioprotective action is much less (on a small sample). Other materials containing hydroxyl functions were tested but none was effective; the present drug is not so effective as AET and appears to diminish its radioprotective effect. Butyrolactone has a similar action to that of 4-hydroxybutyrate; other anesthetics do not. Several suggestions are proposed to explain the narcotic effect. 4-Hydroxybutyrate may stimulate the pentose- phospate pathway, inducing sleep and perhaps arresting the chain of peroxidation reactions. Alternately it may enter into the gamma -aminobutyric acid cycle. The drug does not have the toxic effect of AET. Its value appears to be its usefulness in prolonged radiodiagnostic procedures involving anesthesia; it serves then as an anesthetic and diminishes the effect of radiation dose to some extent. (BBB)
- Research Organization:
- Hopital Boucicaut, Paris
- NSA Number:
- NSA-18-013565
- OSTI ID:
- 4087008
- Journal Information:
- Agressologie (France), Journal Name: Agressologie (France) Vol. Vol: 3; ISSN AGSOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
Similar Records
The action of central nervous systems stimulants in the irradiated animal
The Action of Chlordiazepoxide on Metabolism and Body Temperature of the Mouse: Data on the Mechanism of Action of Radioprotective Agents
RADIOPROTECTION IN PRIMATES. A preliminary Report
Journal Article
·
Tue Feb 28 23:00:00 EST 1961
· Naunyn-Schmiedeberg's Archives of Pharmacology
·
OSTI ID:4723968
The Action of Chlordiazepoxide on Metabolism and Body Temperature of the Mouse: Data on the Mechanism of Action of Radioprotective Agents
Journal Article
·
Sun Dec 31 23:00:00 EST 1961
· Z. Ges. Exptl. Med.
·
OSTI ID:4688399
RADIOPROTECTION IN PRIMATES. A preliminary Report
Technical Report
·
Sat Dec 31 23:00:00 EST 1960
·
OSTI ID:4026002