The action of central nervous systems stimulants in the irradiated animal
Journal Article
·
· Naunyn-Schmiedeberg's Archives of Pharmacology
Attempts were made to determine the action of ionizing radiation on the central nervous system by its altered response to various drugs after irradiation. The influence of the drugs was tested by injecting them in mice 30 min before and 30 min or 6 days after whole-body irradiation with 400 r. Irradiation did not alter the LD50 of any of the drugs: adrenaline, ephedrine, amphetamine, Pervitin (d-deoxyephedrine), and eventin. Slightly greater toxicity symptoms were noted with amphetamine after irradiation. The convulsive death of rats irradiated with high doses (up to 15000 r) was not altered by injection of the central stimulant Metrazole (35 mg/kg). A serous meningoencephalitis was noted in rats irradiated with 15000 r. BETA , BETA '-Iminodipropionitrile, a drug which intensely stimulates the cerebrum and induces a circling activity in mice, was tested for possible radioresistance properties. It significantly increased the LD50 in female mice to 753 r from a control value of 634 r. Irradiation did not potentiate the action of the drug, and its suppressive effect on radioinduced death was no longer evident 6 months after the drug had been given. The results suggest that the action of central stimulants, unlike narcotics, is not greatly affected by irradiation of the central nervous system.
- Research Organization:
- Universitat, Freiburg i.B.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-010263
- OSTI ID:
- 4723968
- Journal Information:
- Naunyn-Schmiedeberg's Archives of Pharmacology, Journal Name: Naunyn-Schmiedeberg's Archives of Pharmacology Journal Issue: 1 Vol. 241; ISSN 0028-1298
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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