ADMINISTRATION OF PERIPHERAL NEUROTROPHIC AGENTS IN THE PROPHYLAXIS OF RADIATION SICKNESS
Journal Article
·
· Folia Biologica (Prague) (Czechoslovakia)
OSTI ID:4223651
Experiments were carried out in 5,582 mice irradiated with a total-body dose of 700 r, and the prophylactic effect of pharmacological substances chiefiy affecting the peripheral parts of the nervous system was studied. Among these compounds, the stimulators had a protective effect, while paralyzing or blocking agents were usually ineffective. The best protective effect was provided by a combination of the two peripheral stimulators adrenaline and acetylcholihe (survival 36%). The protective effect of this combination is associated with the peripheral sympathicotropic action of adrenaline and the mainly M-cholinergic effect of acetylcholine. These substances evidently act via intermediary metabolic products, which can themselves be used as protective anti-radiation agents. (auth)
- Research Organization:
- Inst. of Experimental Pathology and Therapy, Academy of Medical Sciences, U.S.S.R., Suchumi
- NSA Number:
- NSA-13-017695
- OSTI ID:
- 4223651
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 5; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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