RADIOPROTECTION IN PRIMATES. A preliminary Report
In preliminary studies, the radioprotective drug S,betaaminoethylisothiurorium dibromide (AET) was administered to Macaca mulatta monkeys receiving four distinct acute doses of x radiation which would be 75 to 100% lethal in untreated animals. AET was given intravenously, intraperitoneally, and oally. In spite of the small numbers of animals studied, the results indicated that AET given intraperitoneally is not effective at doses above 625 r, AET given intravenously is 50% effective at 700 r, Pentobarbithi sodium in combination with buffered AET (orel), under certain experimental conditions, may be more effective than either drug alone, and the use of cysteine hydrochloride in conjunction with AET appears to potentiate the action of the isothiuronium compound. (auth)
- Research Organization:
- Texas. Univ., Austin. Radiobiological Lab.
- NSA Number:
- NSA-15-016853
- OSTI ID:
- 4026002
- Report Number(s):
- AF-SAM-61-3
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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