ROLE OF THE CENTRAL NERVOUS SYSTEM IN PROCESSES OF RESTITUTION AND COMPENSATION UNDER THE EFFECT OF RADIO-PROTECTIVE AGENTS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Sb. Ved. Praci Lekar. Fak. Karlovy Univ. Hradei Kralove

OSTI ID:4071091

Arbusov, S Ya

Studies were made on the radiation protective and therapeutic effects of drugs against radiation effects on the central nervous system. Mercamine was found to depress the process of excitation in the cerebral cortex. A certain role in the display of defense responses evoked by mercamine administration was found to belong to the sympathetic nervous system. The preliminary administration of sulfurcontaining radioprotective compounds brings about a sedative effect, evolving with time. Imidazole 2-carbonic acid compounds, owing to their sedative effect, prevent any pathological alterations of CNS reactivity. Such a selective effect favors prevention by compensating for radiation injury. The administration of neuroplegic agents (aminazine and phenatine) was found to reduce the extent of impairment and to shorten the time of recovery of a number of unconditioned responses (duration of post-rotatory nystagmus, amount of unconditioned reflex salivation) in treated irradiated animals, as compared to untreated controls. (P.C.H.)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-18-009921
• OSTI ID: 4071091
• Journal Information: Sb. Ved. Praci Lekar. Fak. Karlovy Univ. Hradei Kralove, Journal Name: Sb. Ved. Praci Lekar. Fak. Karlovy Univ. Hradei Kralove Vol. Vol: 6
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AROMATIC HYDROCARBONS
BIOLOGY AND MEDICINE
CARBON DIOXIDE
CHLORPROMAZINE
DRUGS
MEA
NERVOUS SYSTEM
ORGANIC NITROGEN COMPOUNDS
PHENATINE
RADIATION PROTECTION
RECOVERY
REGENERATION
SULFUR COMPOUNDS
TOXICITY
VARIATIONS
WATER