THE EFFECT OF PHENATIN ON THE COURSE AND RESULT OF DAMAGE BY PENETRATING RADIATION
Rabbits were irradiated with 800 r of Co/sup 60/ gamma radiation with a dose intensity of 4.87 r per minute. One part of the animals was given for a period of 24 hours and 30 minutes prior to the irradiation 1 to 3 mg/kg doses of phenatin (a product of condensation of phenamine and nicotinic acid). The administration of phenatin continued following the irradiation (20 days twice daily, and 10 days once daily). The injection of phenatin produced a positive effect upon the course of radiation damage and increased the duration of life. It was possible, by administration of phenatin, to prevent death of 4 out of 10 rabbits while all the control animals perished. The administration of large doses of phenatin (5 and 10 mg/kg) or substitution by thiophenatin delayed death of the rabbits to a sinall degree only. The administration of phenatin prevented the drop of leukocytes. Combination of pheratin with bicaptan-mercamine is recommended.
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-14-013654
- OSTI ID:
- 4172982
- Journal Information:
- Fiziol. Zhur. S.S.S.R., Journal Name: Fiziol. Zhur. S.S.S.R. Vol. Vol: 43
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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