PHARMACOLOGICAL CHARACTERISTICS OF BECAPTAN ($beta$-MERCAPTOETHYLAMINE) AND ITS EFFECTS ON THE COURSE AND OUTCOME OF RADIATION SICKNESS (in Russian)
Mice (weight 18 to 26 g) were irradiated with a dose of 700 r. It was found that previous administration of doses of phenatine (1 to 3 mg/kg), propyl-2- phenamine (1.00 mg/kgl, and phenylphenamine (2 to 25 mg/kg) had a beneficial effect in increasing the time of survival and the number of survivals. Substances which paralyze the nervous system such as atropine (0.0124 mg per mouse) and spherophysin (0.3 to 0.6 mg per mouse) were ineffective. Of the sulfur-containing substances it was found that dinicotinylsulfide (3 mg per animal) and psraminobenzene disulfide (l mg per mouse) had no effect on the outcome of radiation sickness. A study of the ercaptoethylamine derivative, diethyldisulfldemercaptoethylamine (dose of 2 mg per mouse), showed that these substances possessed no protective action and were more toxic than becaptan. lt was found that the relative toxicity of the new salts of BETA mercaptoethylsmine, the ascorbate and the nicotinate, was 0.6 compared to 1.1 for salicylate salt and 1.0 for BETA mercaptoethylamine itseif. These new salts (dose of 3 mg per mouse) were as effective as becaptan in moderating the outcome of severe radiation sickness. Administration of 3 mg of becaptan with 0.0125 mg of atropine per mouse before irradiation was more effective than the use of becaptan by itself. A decrease in blood pressure was observed at doses of 5 to 30 mg/kg of becaptan. A decrease in the hypotension effect was noted after dosing with atropine. In large doses (70 to 100 mg/kg) the reflexes of the spinal cord were slowed down in rabbits, particularly under narcosis. Because of these side effects it is desirable to use becaptan in combination with atropine and other substances. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-15-002548
- OSTI ID:
- 4125576
- Journal Information:
- Trudy Vsesoyuz. Konf. Med. Radiol., Journal Name: Trudy Vsesoyuz. Konf. Med. Radiol.
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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