EFFECTS OF RADIATION ON NUCLEIC ACID METABOLISM IN MICE. II. EFFECT OF BETA-MERCAPTOETHYLAMINE-HCl (MEA) AND BETA-AMINO-ETHYL-ISOTHIURONIUM-HBr (AET) ON NUCLEIC ACID CONTENT IN THE THYMUS, SPLEEN AND TESTES

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4054769

Yamamoto, G

Effects of chemical protective agents on nucleic acid metsbolism after irradiation were studied, using adult mice of (NH x CBA) F/sub 1/, C/sub 5//sub 7/ Bl, and CBH strains. MEA was administered intraperitoneally 10 to 30 min before or after x irradiation with 300 r, while AET was administered before x irradiation with 680 r. When MEA was injected, the nucleic acid metsbolism in the thymus and spleen was sppreciably depressed about one day later. In the spleen as well as in the testis, only the Post-treatment was protective sgainst x irradiation, particularly when MEA was adminis- tered in the most depressed stage of metabolism. Neither MEA nor AET was effective, as pre-treatment. (auth)

• Research Organization: Kyoto Univ.
• NSA Number: NSA-15-020609
• OSTI ID: 4054769
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINES
BIOLOGY AND MEDICINE
CHEMICALS
GLANDS
GONADS
METABOLISM
MICE
NUCLEIC ACIDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
SPLEEN
THIOLS
THYMUS