EFFECTS OF COMBINED USE OF X-RAY AND NITROMIN ON YOSHIDA SARCOMA. VI. STUDY ON THE COMBINED EFFECTS OF RADIATION AND CHEMICALS

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4048326

Motonaga, I

The combined effects of x rays and nitromin (nitrogen mustard) on Yoshida sarcoma were studied. When nitromin (0.1 mg/100 g) was given, mitosis was observed in Yoshida sarcoma cells and each mitotic phase became of markedly low incidence. Morphologically most cells in the metaphase had sticky, coalescent, broken, and scattered chromosomes, while most cells in the anaphase showed chromosome bridges and delay. When x rays were used combined with nitromin administration, the effect of x rays and that of nitromin appeared separately and independently. This may be explained by the so-called covering effect theory. Injection of small amounts of nitromin promoted recovery of mitotic activity of cells damaged by x irradiation. (Abstr. Japan. Med., 1: No. 1, 1960)

• Research Organization: Hokkaido Univ., Sapporo
• NSA Number: NSA-15-022081
• OSTI ID: 4048326
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHEMICALS
CHROMOSOMES
MITOSIS
NITROGEN COMPOUNDS
NITROGEN MUSTARD
RADIATION EFFECTS
RADIATION INJURIES
RECOVERY
TUMORS
X RADIATION