STUDIES ON THE COMBINED EFFECT OF IRRADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XVI. EFFECTS OF COMBINED USE OF X-RAY AND THIO-TEPA ON YOSHIDA SARCOMA

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4048147

Umeno, T

In Yoshida sarcoma of rat, 3 to 4 days after transplantation, the frequency of mitosis, change in number in each mitotic phase, and the frequency of chromosome abnormalities in the metaphase and anaphase were observed. ThioTEPA produced a rapid decrease in number of mitotic cells, which were fewest 9 to 12 hr after injection. Thereafter, they gradually increased in number, but did not return to pre-treatment levels, even at 48 hr. Abnormal chromosomes showing signs of stickiness and/or condensation were observed in the metaphase, and chromosome bridges induced by breskage and stickiness of chromosomes appeared in the anaphase. These so-called radiomimetic effects resemble those of x ray. Combined use of thio-TEPA with x rays showed independent effects, though irradiation atfer injection resulted in a stronger effect than injection alone, and irradiation before injection reduced the effect of thio-TEPA. (Absts. Japan. Med., 1: No. 7, 1960.)

• Research Organization: Hokkaido Univ., Sapporo
• NSA Number: NSA-15-022103
• OSTI ID: 4048147
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHEMICALS
CHROMOSOMES
DRUGS
IRRADIATION
MITOSIS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RATS
THIO-TEPA
THIOLS
TRANSPLANTS
TUMORS
X RADIATION