STUDIES ON THE COMBINED EFFECT OF RADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XII. EFFECT OF COMBINED USE OF X-RAY AND ZnSO$sub 4$
The effects on sarcoma cells of ZnSO/sub 4/ alone and combined with x rays were tested. The material used was MTK sarcoma 111 of rat, 3 to 4 days after transplantation. An aqueous solution of ZnSO/sub 4/ was injected intraperitoneally and the frequency of mitosis, the percentage of each mitotic phase, and the frequency of abnormal chromosomes in the metaphase were determined. ZnSO/sub 4/ caused a considerable increase in mitoses of sarcoma cells, mitotic cells being increased in the metaphase, anaphase, snd telephase, and decreased in the prophase. In the metaphase, many abnormal chromosomes showed clumping. Injection of ZnSO/sub 4/ before x irradiation counteracted the x-ray effect of decreasing mitoses. The peak effect appeared 6 hr after injection. Injection of ZnSO/sub 4/ after x irradiation did not change the effect of irradiation. Injection of ZnSO/sub 4/ before irradiation also provided some protection against the lethal effects of radiation. (Abstr. Japan Med., 1: No. 8, 1961)
- Research Organization:
- Hokkaido Univ., Sapporo
- NSA Number:
- NSA-15-022091
- OSTI ID:
- 4045190
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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