EFFECT OF RADIATION ON THE ELECTROKINETIC POTENTIAL OF SARCOMA CELLS. VI. EFFECT OF COMBINED USE OF X-RAY AND ANTICANCEROUS AGENTS
The effect of the combined use of x rays snd anticancerous agents on the electrokinetic potential on the sarcoma cell surface was examined by means of microelectrophoresis. Sarcoma MTK-111 in rats was irradiated by x rays ranging in dose from 200 to 2,000 r followed by intraperitoneal injection of an anticancerous agent. The electrophoretic mobility of untreated sarcoma cells was on the average (5 plus or minus 0.007) x 10/sup -//sup 4/ cm/sec/volt/cm in 460 cases. This value was almost independent of the time since implantation of the sarcoma and of the frequency of punctures for sampling ascites. When irradiated in vivo the electrophoretic mobility of the sarcoma cells showed a transient decrease. The isoelectric point of the cell potential was not changed by x irradiation nor by injection of the agents nor by the combined use of them. X irradiation in vivo produccd little effect on the electrophoretic mobility of the sarcoma cells, which was more or less decreased after the use of the anticancerous agents. Generally the combined use of x rays and anticancerous agents had a cumulative effect. (Abstr. Japan. Med., 1: No. 1, 1960)
- Research Organization:
- Hokkaido Univ., Sapporo
- NSA Number:
- NSA-15-022077
- OSTI ID:
- 4044322
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
STUDIES ON THE COMBINED EFFECT OF RADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XII. EFFECT OF COMBINED USE OF X-RAY AND ZnSO$sub 4$
STUDY ON THE COMBINED EFFECTS OF RADIATION AND CHEMICALS. VIII. EFFECT OF THE COMBINED USE OF X-RAYS WITH FUMARIC AND MALONIC ACID ON SARCOMA MTK-III