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THE PHOSPHORILATION IN LIVER AND KIDNEY OF RATS TREATED WITH FRACTIONS OF HOMOLOGOUS HOMOGENATES OF ORGANS BELONGING TO IRRADIATED ANIMALS (in Italian)

Journal Article · · Sperimentale (Italy)
OSTI ID:4041587

Experiments were planned with the aim of detecting the fraction of the tctal homogenate responsible for the mor phologic and biochemical mitochondrial lesions observed in normal animals. Nuclei, mitochondria, and supernatant liquld of the total homogenate were separated by fractionated centrifugation. Each fraction was adiministered to normal rats by penitoneal injection. It was seen that the nuclear and mitochondria fractions did not induce any cellular damage (P/ O dissociation, swelling, or changing of shape of the mitochondria). The supernatant fluid. which residuated after sedimentation of the mitochondria, was responable for the cellular damage. (auth)

Research Organization:
Universita, Genoa
NSA Number:
NSA-15-023272
OSTI ID:
4041587
Journal Information:
Sperimentale (Italy), Journal Name: Sperimentale (Italy) Vol. Vol: 3; ISSN SPERA
Country of Publication:
Country unknown/Code not available
Language:
Italian