AORTIC ARTERIOSCLEROSIS IN THE DOG FOLLOWING LOCALIZED AORTIC IRRADIATION WITH ELECTRONS

Technical Report · Wed May 24 04:00:00 EDT 1961

OSTI ID:4041418

Lindsay, S; Entenman, C; Shumway, B W; Ellis, E E; Geraci, G L; Skahen, R

The inferior segments of the abdominal aortas of 15 dogs were irradiated at electron doses from 1000 to 9500 rads, and were examined histologically at intervals ranging from 2 weeks to 17 months following irradiation. Pronounced aortic arteriosclerosis developed and was sharply localized to the aortic segment irradiated. Except in one dog, radiation-induced arteriosclerosis was more pronounced on the dorsal than on the ventral aortic wall. There was no evidence that severity of aortic arteriosclerosis was related to the dose of irradiation or was increased with time following irradiation. The development of arteriosclerotic lesions of the aorta induced by electron irradiation was similar to that observed after x-irradiation and to that occuring naturally in old dogs. It is suggested that electron irradiation may have caused selective injury of the internal elastic lamina, which was then followed by intimal fibrous proliferation and formation of intimal plaques. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-15-023293
• OSTI ID: 4041418
• Report Number(s): USNRDL-TR-512
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
AORTA
ARTERIOSCLEROSIS
BIOLOGY AND MEDICINE
BLOOD VESSELS
DISEASES
DOGS
ELECTRONS
IRRADIATION
RADIATION DOSES
RADIATION EFFECTS
X RADIATION