An Experimental Study of Endovascular Stenting with Special Reference to the Effects on the Aortic Vasa Vasorum

Journal Article · Thu Jan 15 04:00:00 EST 1998 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S002709900210· OSTI ID:21080450

Sanada, Jun-Ichiro; Matsui, Osamu; Yoshikawa, Jun; Matsuoka, Toshihiko ^[1]

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1. Department of Radiology, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa 920 (Japan)

Purpose: To evaluate the effects of bare stents and covered stents on the aortic wall, especially the vasa vasorum. Methods: Eight bare stents and nine covered stents were placed in the infrarenal aorta of nine dogs. The dogs were euthanized at 4-45 weeks after stent placement. The vasa vasorum was evaluated by microstereoscopy with vascular casting, and the histopathology of the aortic wall was examined by light microscopy. Results: In the unstented normal aorta, vasa vasorum nourished the adventitia and the outer media, and the intima and inner media were avascular. In the stented segment, vascular dilatation and proliferation of vasa vasorum, medial atrophy, and intimal hyperplasia were observed, more prominent for covered stents than for bare stents. Conclusion: Intravascular stent placement caused not only medial atrophy and intimal hyperplasia but also proliferation of the vasa vasorum, probably due to hypoxia in the aortic wall.

• OSTI ID: 21080450
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 1 Vol. 21; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANOXIA
AORTA
ATROPHY
DOGS
MICROSCOPY