EFFECTS OF GAMMA RADIATION ON ISOLATED SURVIVING ARTERIES AND THEIR VASA VASORUM

Journal Article · Wed Nov 01 04:00:00 EST 1961 · American Journal of Physiology (U.S.)

OSTI ID:4831420

Smith, D J

The effects of irradiation wlth Co/sup 60/ on l36 swine and dog carotld arterles were studled in vitro, utilizing an angioplethysmokymographic technlque. In 20 to 40% of the specimens a sllght vasoconstriction of the arterial wall was observed. This began and was completed wlthln the flrst 60 sec of lrradlation. Mounting the tlssue ln mineral oil did not prevent this reactlon. Marked reductlons ln vasa vasorum flow were observed ln swine carotids (70% decrease) and dog carotids (50% decrease) exposed to 9390 r of gamma radiation during l5 min. Less marked, although signlflcant, decreases ln vasa vasorum flow were seen ln swlne arteries exposed to 3000 r, 2085 r, and l500 r. No significant decreases were observed ln 24 arteries exposed to 843 r. Swine arterles exposed to 9390 r, while mounted ln mineral oil, did not show a significant decrease ln vasa vasorum flow. It ls concluded that the contractlon of the arterlal wall was a direct effect of radiation upon the vascular smooth muscle and that the observed decrease ln vasa flow was probably secondary to ionlzatlon of the Tyrode's solution surroundlng the artery. (auth)

• Research Organization: Univ. of Vermont, Burlington
• NSA Number: NSA-16-001502
• OSTI ID: 4831420
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 201; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD VESSELS
COBALT 60
GAMMA RADIATION
MUSCLES
RADIATION DOSES
RADIATION EFFECTS
RECORDING SYSTEMS
SWINE