Coronary arteriosclerosis and atherosclerosis in fast neutron or photon irradiated dogs

Journal Article · Sat Aug 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90169-3· OSTI ID:5887230

Bradley, E W ^[1]; Zook, B C; Casarett, G W

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1. George Washington Univ. Medical Center, Washington, DC

Thirty-nine adult male beagles received either fast neutron or photon irradiation to the right thorax to obtain values for the relative biological effectiveness (RBE) of fast neutrons as assessed by quantitative parameters of lung function. Fast neutrons (15 MeV avg.) were delivered in 4 fx/wk for six weeks to total doses of 1000, 1500, 2250, or 3375 rad while the photon irradiated dogs received total doses of 3000, 4500, or 6750 rad in the same fractionation schedule. The right atrium and coronary groove of the heart were included in the irradiated field. Cholesterol levels (and triglyceride levels when obtainable) were measured prior to irradiation and every three months until death. Arteries were graded (0, negative to 5, severe) for endothelial proliferation, disruption and duplication of the elastic lamina, perivascular fibrosis and the presence of foamy macrophages. All dogs that survived 75 days post-irradiation developed arterial changes; two neutron irradiated dogs showed severe atherosclerotic plaque formation. Data suggest an RBE between 4 and 5.

• OSTI ID: 5887230
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTERIES
ARTERIOSCLEROSIS
BARYONS
BEAGLES
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DOGS
DOSES
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
HADRONS
HEART
LUNGS
MAMMALS
MEDICINE
NEUTRON BEAMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
ORGANS
PARTICLE BEAMS
PHOTON BEAMS
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RBE
RESPIRATORY SYSTEM
THERAPY
VASCULAR DISEASES
VERTEBRATES