Effects of fractionated doses of fast neutrons and photons on the normal canine lung: relative biological effectiveness values obtained by radionuclide studies. [Exposures in therapeutic dose range (4000 to 6000 rad)]

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90720-X· OSTI ID:5566737

Bradley, E W; Alderson, P O; Deye, J A; Mendenhall, K G; Fisher, M P; Vieras, F; Rogers, C C

Thirty nine adult male beagles received either fast neutron or photon irradiation to the right thorax. There were 2 unirradiated control dogs. Twenty four dogs received fast neutrons with a mean energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 rad delivered in 4 fx/wk for 6 weeks. Fifteen dogs received total doses of 3000, 4500 or 6750 rad of photons (/sup 60/Co) in the same fractionation pattern. Radionuclide evaluations of pulmonary function were performed pre-irradiation and every three months post-irradiation for 1 year. These included: (1) radioaerosol deposition of an insoluble radiocolloid, /sup 99m/Tc-phytate; (2) /sup 133/Xe ventilation studies; and (3) /sup 99m/Tc-macroaggregated albumin perfusion images. Values for the relative biological effectiveness (RBE) of fast neutrons in producing changes in these parameters have been obtained by plotting the changes from pre-irradiation values in the right lung as function of the total dose. RBE values for the relative deposition of aerosol and the relative distribution of volume and perfusion have been obtained at 3, 6, 9 and 12 months post-irradiation. The relative biological effectiveness (RBE) for neutron damage to normal lung tissue was always greater than 4 in the clinical dose range of 4000 to 6000 rad of photons.

• Research Organization: George Washington University, Washington, DC
• OSTI ID: 5566737
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

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550900 -- Pathology
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560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMALS
BARYONS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHEST
COBALT 60
COBALT ISOTOPES
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
ESTERS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HADRONS
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
LUNGS
MAMMALS
MEV RANGE
MEV RANGE 10-100
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PHOSPHORIC ACID ESTERS
PHYTIC ACID
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RBE
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES