Comparison of neutron RBE values for normal canine lung by densitometry, pulmonary function, and radionuclide studies

Journal Article · Sat Aug 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90159-0· OSTI ID:5819764

Bradley, E W ^[1]; Alderson, P O; McWhorter, R E

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1. George Washington Univ., Washington, DC

Thirty-nine adult male beagles received either fast neutron or photon irradiation to the right thorax. There were two unirradiated control dogs. Twenty-four dogs received fast neutrons with a mean energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 rad delivered in four fractions per week for six weeks. Fifteen dogs received total doses of 3000, 4500, or 6750 rad of photons (/sup 60/Co) in the same fractionation pattern. Radionuclide evaluations of pulmonary function were performed pre-irradiation and every three months post-irradiation for two years. These included: (1) radioaerosol deposition of /sup 99 m/Tc-phytate, an insoluble radiocolloid, (2) /sup 133/Xe ventilation studies, and (3) /sup 99 m/Tc-macroaggregated albumin perfusion images. A chest radiograph taken prior to each radionuclide evaluation was measured for density changes. Mechanical properties of pulmonary function were studied pre-irradiation and at 3-month intervals post-irradiation for one year. Values for the relative biological effectiveness (RBE) of fast neutrons in producing changes in these parameters were obtained by plotting the changes from pre-irradiation values in the right lung as a function of the total dose. The RBE for neutron damage to normal lung tissue was always greater than 4 in the clinical dose range of 4000 to 6000 rad of photons, regardless of the parameter that was used to generate the value.

• OSTI ID: 5819764
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BEAGLES
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
DOSES
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
FAST NEUTRONS
FERMIONS
HADRONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEUTRON BEAMS
NEUTRONS
NUCLEI
NUCLEON BEAMS
NUCLEONS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTICLE BEAMS
PHOTON BEAMS
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOSENSITIVITY
RBE
RESPIRATORY SYSTEM
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES