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THE PROTECTIVE EFFECTS OF $beta$-AMINO-ETHYLISOTHIURONIUM/center dot/Br/ center dot/HBr AND p-AMINOPROPIOPHENONE AGAINST ACUTE LETHAL WHOLE-BODY X-IRRADIATION IN DOGS

Journal Article · · Radiation Res.
DOI:https://doi.org/10.2307/3571648· OSTI ID:4032688
In mongrel dogs, a combination of 175 mg of AET and 3.5 mg of PAPP-kg provided 100% protection in dogs exposed to 550 r of whole-body x irradiation and also protected 5 of 6 animals given 650 r. Some degree of protection at 800 r was also found. Either drug alone failed to protect dogs against 550 r, which indicates that their protective effects are additive. The drugs were administered orally in enteric-coated intermittent-release preparations 3 to 4 hr prior to irradiation. (auth)
Research Organization:
Univ. of Tennessee, Memphis
Sponsoring Organization:
USDOE
NSA Number:
NSA-18-019794
OSTI ID:
4032688
Journal Information:
Radiation Res., Journal Name: Radiation Res. Vol. Vol: 21
Country of Publication:
Country unknown/Code not available
Language:
English

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