REDUCTION OF RADIATION LETHALITY IN DOGS BY CHEMICAL MIXTURE

Technical Report · Mon May 01 04:00:00 EDT 1961

OSTI ID:4843074

Wang, R I.H.; Davidson, Jr, D E

BS>A total of 68 small dogs were individually exposed to supra-lethal doses of 600 r (1.8 x LD/sub 100/) of acute wholebody radiation from a cobalt 60 source. The administration of 4 to 5 mg/kg of para-amino-propiophenone (PAPP) intravenously 30 minutes before, and 225 mg (total dose) of S,P- aminoethylisothiuronium (AET) plus 32.5 mg (tctal dose) of serotonin intraperitoneally 10 to 15 minutes before irradiation provided 58% survival, whereas the administration of PAPP alone protected only 13%. By supplementing this pre-irradiation chemical treatment with post-irradiation supportive therapy consisting of antibiotics, vitamins, parente ral fluids, and whole-blood transfusions, the survival of the PAPP treated dogs was increased to 63%, while the survival of the dogs receiving the chemical mixture was increased to 82%. Post-irradiation supportive therapy increased the mean survival time of control irradiated dogs by 4 days, but effected survival beyond 30 days in only one case. Pre-treatment with chemical agents seemed to influence favorably the postirradiation fall in leakocytes, but did not noticeably affect the hematocrit or hemoglobin levels. No deaths occurred as a direct result of the toxicity of the chemical agents; furthermore, the intravenous administration of methylene blue immediately following irradiation rapidly reversed the toxic effects. (auth)

• Research Organization: Army Medical Research Lab., Fort Knox, Ky.
• NSA Number: NSA-15-028985
• OSTI ID: 4843074
• Report Number(s): AMRL-484
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
ANTIBIOTICS
BIOLOGY AND MEDICINE
BLOOD
CHEMICALS
COBALT 60
DOGS
DYES
IRRADIATION
LETHAL DOSE
LIFETIME
METHYLENE BLUE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PAPP
SULFUR
TOXICITY
TRANSFUSIONS
VITAMINS