Contrast-enhanced MR imaging assessment of tumor capillary permeability: Effect of irradiation on delivery of chemotherapy
- Univ. of California, San Fransisco, CA (United States); and others
To assess the effect of X rays on tumor capillary permeability with macromolecular contrast medium (MMCM)-enhanced magnetic resonance (MR) imaging. One of paired R3230 mammary adenocarcinomas implanted in the flanks of 48 Fischer rats was treated with a single 5- or 15-Gy dose of X rays. After 1 or 3 days, MR imaging in 30 rats was performed unenhanced and enhanced with albumin-(gadolinium diethylenetriminepentaacetic acid){sub 30} (0.02 mmol gadolinium per kilogram body weight). Signal intensity enhancement was analyzed to estimate fractional blood volume and permeability-surface area product (PS). In 18 irradiated rats, 2.5 mg/kg cisplatin was injected intravenously, and fractional tumor platinum concentrations were measured spectrometrically. MR imaging showed highest capillary permeability 1 day after 15 Gy (PS 110% above control [P<.001]); PS was elevated 57% 1 day after 5 Gy and 63% 3 days after 15 Gy (P<.05). The largest mean tumor platinum fraction occurred 1 day after 15 Gy: 48% versus 20% (control) (P<.05). Transient irradiation induced increase in tumor capillary permeability to cisplatin can be quantified with MMCM-enhanced MR imaging. 70 refs., 2 figs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 401799
- Journal Information:
- Radiology, Journal Name: Radiology Journal Issue: 3 Vol. 198; ISSN 0033-8419; ISSN RADLAX
- Country of Publication:
- United States
- Language:
- English
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