Contrast-enhanced magnetic resonance imaging estimation of altered capillary permeability in experimental mammary carcinomas after x-irradiation

Journal Article · Tue Nov 01 04:00:00 EST 1994 · Investigative Radiology

DOI:https://doi.org/10.1097/00004424-199411000-00004· OSTI ID:45250

Cohen, F M; Kuwatsuru, R; Shames, D M; Neuder, M; Mann, J S; Vexler, V; Rosenau, W; Brasch, R C ^[1]

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1. Univ. of California, San Francisco, CA (United States)

Dynamic magnetic resonance imaging (MRI) enhanced with a macromolecular contrast medium, albumin-(Gd-DTPA){sub 35}, was used to detect changes in microvascular characteristics in R3230 mammary adenocarcinomas induced by x-irradiation. Tumors were implanted in either flank in nine rats. One of the tumors was exposed to single-dose x-irradiation (30 Gy) 3 days before MRI. The contralateral control tumor was shielded from irradiation. Capillary permeability to macromolecular contrast medium in irradiated tumors was elevated significantly (P < .05) compared to the control nonirradiated tumors. The mean estimated permeability surface area product for the irradiated tumors increased more than three-fold; 0.511 {+-} .046 mL hr{sup {minus}1} cm{sup {minus}3} compared with 0.121 {+-} .011 mL hr{sup {minus}1} cm{sup {minus}3} for the nonirradiated tumors. This radiation-induced increase in permeability was corroborated using a macromolecular Evans blue-protein complex measured in the same tumors using an invasive spectrophotometric technique. Dynamic MRI-enhanced with macromolecular contrast medium permits noninvasive quantitative estimates of capillary permeability in tumors, with and without x-irradiation. Because the transendothelial permeability for macromolecular solutes likely influences tumoral accumulation of macromolecular chemotherapeutic agents, this noninvasive technique may prove to be clinically useful in tailoring tumor treatment programs which combine radiation and chemotherapy. 51 refs., 4 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 45250
• Journal Information: Investigative Radiology, Journal Name: Investigative Radiology Journal Issue: 11 Vol. 29; ISSN 0020-9996; ISSN INVRAV
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
CARCINOMAS
CHEMOTHERAPY
COMBINED THERAPY
CONTRAST MEDIA
EVANS BLUE
FEASIBILITY STUDIES
IRRADIATION
MAGNETIC RESONANCE
MAMMARY GLANDS
RATS
THERAPEUTIC USES