EFFECT OF X-RAY IRRADIATION ON BLOOD COAGULATION FACTORS IN RABBITS

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Kanazawa Irigaku Sosho (Japan)

OSTI ID:4010745

Yoshida, S

Irradiations of 50 r, 300 r, 750 r (LD/sub 50/), and 1500 r in a single dose were carried out. The number of platelets increased following irradiation of 50 r and decreased with doses larger than 300 r. Single whole-body and abdomial irradiation of 1500 r caused a decrease in the platelet count down to 30000 to 50000 in 10 days and finally death. However, the same irradiation in divided doses resulted in an increase of the platelet count 2 weeks later. Capillary hemorrhages were observed when the platelet count diminished to 30000 to 50000. Coagulation time of whole blood was not altered with 50 r, but was prolonged with doses larger than 300 r. The prolongation reached an abnormal level following single or divided (750 r x 2) whole-body irradiation of 1500 r. According to the thromboplastin generation tsst, a disturbance of the 3rd platelet factor and a decrease in serum factors were present after a single whole- body irradiation of 1500 r, and a decrease in serum factors after a divided whole- body irradiation of 1500 r. The prothrombin time was prolonged, and the fibrinogen concentration fell followig single and divided (750 r x 2) irradiation of 1500 r. (Abstr. Japan Med., 1: No. 9, 1961)

• Research Organization: University School of Medicine, Kanazawa, Japan
• NSA Number: NSA-15-025884
• OSTI ID: 4010745
• Journal Information: Kanazawa Irigaku Sosho (Japan), Journal Name: Kanazawa Irigaku Sosho (Japan) Vol. Vol: 55; ISSN KISOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD SERUM
BLOOD VESSELS
BODY
COAGULATION
HEMORRHAGE
INTESTINE
IRRADIATION
LIFETIME
PLATELETS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
WHOLE-BODY IRRADIATION
X RADIATION