Assignment of the human type I IMP dehydrogenase gene (IMPDH1) to chromosome 7q31.3-q32

Journal Article · Tue Nov 01 00:00:00 EST 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1597· OSTI ID:255227

Gu, Jing Jin; Kaiser-Rogers, K; Rao, K ^[1]

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1. Univ. of North Carolina School of Medicine, Chapel Hill, NC (United States); and others

Two phage {lambda} clones that contain 5{prime} portion of the human type I inosine 5{prime}-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) gene were isolated. Both polymerase chain reaction analysis of a panel of human-mouse and human-hamster cell somatic hybrids using primers specific for the type I IMPDH gene and fluorescence in situ hybridization with metaphase human chromosome using type I IMPDH genomic DNA as probes indicate that the type I IMPDH gene (symbol IMPDH1) is located on chromosome 7. Sequential GTG-banding was performed to assign the band location of the type I IMPDH gene to chromosome 7q31.3-q32. 16 refs., 1 fig., 1 tab.

• OSTI ID: 255227
• Journal Information: Genomics, Vol. 24, Issue 1; Other Information: PBD: 1 Nov 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
NUCLEOTIDE DEHYDROGENASES
GENES
HUMAN CHROMOSOME 7
GENETIC MAPPING
DNA HYBRIDIZATION