New ligands for the asymmetric dihydroxylation
Conference
·
OSTI ID:250065
- Scripps Research Institute, La Jolla, CA (United States); and others
The asymmetric dibydroxylation of olefins in the presence of cinchona alkaloid derivatives (the AD reaction) has proven to be a reliable method in organic syntheses. For most olefins, the enantioselectivities using the {open_quotes}standard{close_quotes} phathalazine ligands are excellent; however, facial selectivity is still moderate for some olefins. 2,3-Diphenyl pyrazinopyridazine (DPP) and anthraquinone (AQN) as spacers for the {open_quotes}pseudo enantiomeric{close_quotes} alkaloids dihydroquinidine (DHQD) or dihydroquinine (DHQ) give superior enantioselectivities for almost all olefins.
- OSTI ID:
- 250065
- Report Number(s):
- CONF-9508100--
- Country of Publication:
- United States
- Language:
- English
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