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Title: Draft Genome Sequence of a Stable Mucoid Strain of Pseudomonas aeruginosa PAO581 with a mucA25 Mutation

Journal Article · · Genome Announcements
 [1];  [1];  [2];  [3];  [4]
  1. Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine. Depts. of Biochemistry and Microbiology
  2. Univ. of Edinburgh, Scotland (United Kingdom). Cystic Fibrosis Lab.
  3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Genome Science Group
  4. Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine. Depts. of Biochemistry and Microbiology; Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine. Dept. of Pediatrics; Progenesis Technologies, LLC, Huntington, WV (United States).
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A mutation in the mucA gene, which encodes a negative regulator of alginate production in Pseudomonas aeruginosa, is the main mechanism underlying the conversion to mucoidy in clinical isolates from patients with cystic fibrosis (CF). Here, we announce the draft genome sequence of the stable alginate-overproducing mucoid strain P. aeruginosa PAO581 with a mucA25 mutation, a derivative from the nonmucoid strains P. aeruginosa PAO381 and PAO1.

Research Organization:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; National Institutes of Health (NIH)
Grant/Contract Number:
P20RR016477; P20GM103434
OSTI ID:
1629281
Journal Information:
Genome Announcements, Vol. 1, Issue 5; ISSN 2169-8287
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

References (8)

ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa journal July 2008
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia journal September 1996
Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro journal January 1978
Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa: Proteolytic regulation of alginate journal April 2012
Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis: P. aeruginosa pathogenesis journal February 2005
Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. journal January 1996
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. journal September 1993
Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa journal June 1995

Cited By (1)

Genome sequence of Pseudomonas aeruginosa PAO1161, a PAO1 derivative with the ICEPae1161 integrative and conjugative element journal January 2020

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