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Draft Genome Sequences of Two Alginate-Overproducing Variants of Pseudomonas aeruginosa, PAO1-VE2 and PAO1-VE13

Journal Article · · Genome Announcements
 [1];  [2];  [3];  [4];  [3]
  1. Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine; DOE/OSTI
  2. Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine
  3. Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine; Progenesis Technologies, LLC, Huntington, WV (United States)
  4. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
+ Show Author Affiliations
The small envelope protein MucE and the sensor kinase KinB are a positive and negative alginate regulator, respectively. Here, we announce the draft genome sequences of the alginate-overproducing variants Pseudomonas aeruginosa PAO1-VE2 (PAO1 with constitutive expression of mucE) and PAO1-VE13 (PAO1 with kinB inactivated). Both mutants were generated from a transposon mutagenesis screen.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
Cystic Fibrosis Foundation; National Aeronautics and Space Administration West Virginia Space Grant Consortium (NASA WVSGC); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
OSTI ID:
1629279
Journal Information:
Genome Announcements, Journal Name: Genome Announcements Journal Issue: 6 Vol. 1; ISSN 2169-8287
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

References (7)

Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa journal April 2007
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. journal September 1993
The Pseudomonas aeruginosa Sensor Kinase KinB Negatively Controls Alginate Production through AlgW-Dependent MucA Proteolysis journal January 2009
Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis: P. aeruginosa pathogenesis journal February 2005
Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa: Proteolytic regulation of alginate journal April 2012
The Pseudomonas aeruginosa Sensor Kinase KinB Negatively Controls Alginate Production through AlgW-Dependent MucA Proteolysis journal January 2009
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia journal September 1996

Cited By (1)

RNASeq Based Transcriptional Profiling of Pseudomonas aeruginosa PA14 after Short- and Long-Term Anoxic Cultivation in Synthetic Cystic Fibrosis Sputum Medium text January 2016

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES