Distinguishing enantiomeric amino acids with chiral cyclodextrin adducts and structures for lossless ion manipulations

Nagy, Gabe; Chouinard, Christopher D.; Attah, Isaac K.; Webb, Ian K.; Garimella, Sandilya V.  B.; Ibrahim, Yehia M.; Baker, Erin S.; Smith, Richard D.

doi:10.1002/elps.201800294

Distinguishing enantiomeric amino acids with chiral cyclodextrin adducts and structures for lossless ion manipulations

Journal Article · Mon Sep 17 04:00:00 EDT 2018 · Electrophoresis (Weinheim)

DOI:https://doi.org/10.1002/elps.201800294· OSTI ID:1496792

Nagy, Gabe ^[1]; Chouinard, Christopher D. ^[1]; Attah, Isaac K. ^[1]; Webb, Ian K. ^[1]; Garimella, Sandilya V. B. ^[1]; Ibrahim, Yehia M. ^[1]; Baker, Erin S. ^[1]; ^[1]

Biological Sciences DivisionPacific Northwest National Laboratory Richland USA

Enantiomeric molecular evaluations remain an enormous challenge for current analytical techniques. To date, derivatizations strategies and long separation times are generally required in these studies, and the development and implementation of new approaches is greatly desired to increase speed and distinguish currently unresolvable compounds. Herein, we describe a method using chiral cyclodextrin adducts and structures for lossless ion manipulations (SLIM) ion mobility to achieve rapid, high resolution separations of D and L enantiomeric amino acids. In the analyses, chiral cyclodextrin adducts are added to each sample. Two cyclodextrins were found to sandwich each amino acid and form host-guest noncovalent complexes that were distinct for each D and L amino acid pair studied and thus separable with ion mobility (IM) in SLIM devices. The SLIM was also used to accumulate much larger ion populations than previously feasible for evaluation and therefore allow enantiomeric measurements of higher sensitivity and resolution than previously reported by any other IM-based approach.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1496792

Report Number(s):: PNNL-SA-136376

Journal Information:: Electrophoresis (Weinheim), Journal Name: Electrophoresis (Weinheim) Journal Issue: 24 Vol. 39; ISSN 0173-0835

Publisher:: Wiley

Country of Publication:: United States

Language:: English

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