Use of a macrocyclic antibiotic as the chiral selector for enantiomeric separations by TLC

Journal Article · Sat Jan 01 04:00:00 EST 1994 · Journal of Liquid Chromatography; (United States)

DOI:https://doi.org/10.1080/10826079408013451· OSTI ID:7254111

Armstrong, D W; Zhou, Y ^[1]

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1. Univ. of Missouri, Rolla, MO (United States). Dept. of Chemistry

The macrocyclic antibiotic, vancomycin, was used as a chiral mobile phase additive for the thin layer chromatographic (TLC) resolution of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatized amino acids, racemic drugs and dansyl-amino acids. Excellent separations were achieved for most of these compounds in the reversed phase mode. Both the nature of the stationary phase and the composition of the mobile phase strongly influenced enantiomeric resolution. The best results were obtained using diphenyl stationary phases. Acetonitrile was the organic modifier that produced the most effective separations with the shortest development times. It is highly likely that macrocyclic antibiotics will play a major role in future enantiomeric separations.

• DOE Contract Number: FG02-88ER13819
• OSTI ID: 7254111
• Journal Information: Journal of Liquid Chromatography; (United States), Journal Name: Journal of Liquid Chromatography; (United States) Vol. 17:8; ISSN 0148-3919; ISSN JLCHD8
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
CHEMICAL COMPOSITION
CHROMATOGRAPHY
DRUGS
PHASE STUDIES
SEPARATION PROCESSES
THIN-LAYER CHROMATOGRAPHY