Dichotomous development of the gut microbiome in preterm infants

Ho, Thao T.  B.; Groer, Maureen W.; Kane, Bradley; Yee, Alyson L.; Torres, Benjamin A.; Gilbert, Jack A.; Maheshwari, Akhil

doi:10.1186/s40168-018-0547-8

Dichotomous development of the gut microbiome in preterm infants

Journal Article · Wed Sep 12 00:00:00 EDT 2018 · Microbiome

DOI:https://doi.org/10.1186/s40168-018-0547-8· OSTI ID:1493912

Ho, Thao T. B. ^[1]; Groer, Maureen W. ^[2]; Kane, Bradley ^[3]; Yee, Alyson L. ^[4]; Torres, Benjamin A. ^[1]; Gilbert, Jack A. ^[5]; Maheshwari, Akhil ^[6]

Univ. of South Florida, Tampa, FL (United States). Dept. of Pediatrics. Morsani College of Medicine
Univ. of South Florida, Tampa, FL (United States). Dept. of Pediatrics. Morsani College of Medicine. College of Nursing
Univ. of South Florida, Tampa, FL (United States). College of Nursing
Univ. of Chicago, IL (United States). Interdisciplinary Scientist Training Program. Microbiome Center. Dept. of Surgery
Univ. of Chicago, IL (United States). Microbiome Center. Dept. of Surgery; Argonne National Lab. (ANL), Argonne, IL (United States)
Univ. of South Florida, Tampa, FL (United States). Dept. of Pediatrics. Morsani College of Medicine; Johns Hopkins Univ., Baltimore, MD (United States). Dept. of Pediatrics

Preterm infants are at risk of developing intestinal dysbiosis with an increased proportion of Gammaproteobacteria. In this study, we sought the clinical determinants of the relative abundance of feces-associated Gammaproteobacteria in very low birth weight (VLBW) infants. Fecal microbiome was characterized at ≤ 2 weeks and during the 3rd and 4th weeks after birth, by 16S rRNA amplicon sequencing. Maternal and infant clinical characteristics were extracted from electronic medical records. Data were analyzed by linear mixed modeling and linear regression. Clinical data and fecal microbiome profiles of 45 VLBW infants (gestational age 27.9 ± 2.2 weeks; birth weight 1126 ± 208 g) were studied. Three stool samples were analyzed for each infant at mean postnatal ages of 9.9 ± 3, 20.7 ± 4.1, and 29.4 ± 4.9 days. The average relative abundance of Gammaproteobacteria was 42.5% (0–90%) at ≤ 2 weeks, 69.7% (29.9–86.9%) in the 3rd, and 75.5% (54.5–86%) in the 4th week (p < 0.001). Hierarchical and K-means clustering identified two distinct subgroups: cluster 1 started with comparatively low abundance that increased with time, whereas cluster 2 began with a greater abundance at ≤ 2 weeks (p < 0.001) that decreased over time. Both groups resembled each other by the 3rd week. Single variants of Klebsiella and Staphylococcus described variance in community structure between clusters and were shared between all infants, suggesting a common, hospital-derived source. Fecal Gammaproteobacteria was positively associated with vaginal delivery and antenatal steroids. We detected a dichotomy in gut microbiome assembly in preterm infants: some preterm infants started with low relative gammaproteobacterial abundance in stool that increased as a function of postnatal age, whereas others began with and maintained high abundance. Vaginal birth and antenatal steroids were identified as predictors of Gammaproteobacteria abundance in the early (≤ 2 weeks) and later (3rd and 4th weeks) stool samples, respectively. These findings are important in understanding the development of the gut microbiome in premature infants.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of South Florida, Tampa, FL (United States); Univ. of Chicago, IL (United States); Johns Hopkins Univ., Baltimore, MD (United States)

Sponsoring Organization:: USDOE; National Inst. of Health (NIH) (United States)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1493912

Journal Information:: Microbiome, Journal Name: Microbiome Vol. 6; ISSN 2049-2618

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls Stewart, Christopher; Embleton, Nicholas; Marrs, Emma Figshare https://doi.org/10.6084/m9.figshare.c.3825310.v1	collection	January 2017
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Gammaproteobacteria
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very low birth weight infant

Additional file 1: of Dichotomous development of the gut microbiome in preterm infants Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.7082117 The current record is supplemented by this dataset	dataset	September 2018
Additional file 1: of Dichotomous development of the gut microbiome in preterm infants Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.7082117.v1 The current record is supplemented by this dataset	dataset	September 2018
Additional file 2: of Dichotomous development of the gut microbiome in preterm infants Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.7082135 The current record is supplemented by this figure	figure	September 2018
Additional file 2: of Dichotomous development of the gut microbiome in preterm infants Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.7082135.v1 The current record is supplemented by this figure	figure	September 2018
Additional file 3: of Dichotomous development of the gut microbiome in preterm infants Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.7082159 The current record is supplemented by this dataset	dataset	September 2018
Additional file 3: of Dichotomous development of the gut microbiome in preterm infants Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.7082159.v1 The current record is supplemented by this dataset	dataset	September 2018
Dichotomous development of the gut microbiome in preterm infants [Supplemental Data] Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.c.4230917 The current record is supplemented by this collection	collection	September 2018
Dichotomous development of the gut microbiome in preterm infants [Supplemental Data] Ho, Thao; Groer, Maureen; Kane, Bradley https://doi.org/10.6084/m9.figshare.c.4230917.v1 The current record is supplemented by this collection	collection	September 2018

Dichotomous development of the gut microbiome in preterm infants

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