Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition

Lou, Yue Clare; Olm, Matthew R.; Diamond, Spencer; Crits-Christoph, Alexander; Firek, Brian A.; Baker, Robyn; Morowitz, Michael J.; Banfield, Jillian F.

doi:10.1016/j.xcrm.2021.100393

Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition

Journal Article · Tue Sep 07 00:00:00 EDT 2021 · Cell Reports Medicine

DOI:https://doi.org/10.1016/j.xcrm.2021.100393· OSTI ID:2470964

Lou, Yue Clare ^[1]; Olm, Matthew R. ^[2]; Diamond, Spencer ^[1]; Crits-Christoph, Alexander ^[1]; Firek, Brian A. ^[3]; Baker, Robyn ^[3]; Morowitz, Michael J. ^[3]; Banfield, Jillian F. ^[4]

University of California, Berkeley, CA (United States)
Stanford University School of Medicine, CA (United States)
University of Pittsburgh School of Medicine, PA (United States)
University of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Chan Zuckerberg Biohub, San Francisco, CA (United States)

Gut microbiome succession affects infant development. However, it remains unclear what factors promote persistence of initial bacterial colonizers in the developing gut. Here, we perform strain-resolved analyses to compare gut colonization of preterm and full-term infants throughout the first year of life and evaluate associations between strain persistence and strain origin as well as genetic potential. Analysis of fecal metagenomes collected from 13 full-term and 9 preterm infants reveals that infants' initially distinct microbiomes converge by age 1 year. Approximately 11% of early colonizers, primarily Bacteroides and Bifidobacterium, persist during the first year of life, and those are more prevalent in full-term, compared with preterm infants. Examination of 17 mother-infant pairs reveals maternal gut strains are significantly more likely to persist in the infant gut than other strains. Enrichment in genes for surface adhesion, iron acquisition, and carbohydrate degradation may explain persistence of some strains through the first year of life.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470964

Journal Information:: Cell Reports Medicine, Journal Name: Cell Reports Medicine Journal Issue: 9 Vol. 2; ISSN 2666-3791

Publisher:: Cell PressCopyright Statement

Country of Publication:: United States

Language:: English

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Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition

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