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Title: Development of the preterm infant gut microbiome: A research priority

Abstract

The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. In conclusion, the study speculates about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of pretermmore » birth, including its influence on growth, development, and general health of the infant host.« less

Authors:
 [1];  [1];  [2];  [1];  [1];  [3]
  1. Univ. of South Florida, Tampa, FL (United States)
  2. Morsani College of Medicine, St. Petersburg, FL (United States)
  3. Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States); Zhejiang Univ., Hangzhou (China)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1225363
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Microbiome
Additional Journal Information:
Journal Volume: 2; Journal Issue: 1; Journal ID: ISSN 2049-2618
Publisher:
BioMed Central
Country of Publication:
United States
Language:
English
Subject:
preterm infants; VLBW; gut microbiota; health

Citation Formats

Groer, Maureen W., Luciano, Angel A., Dishaw, Larry J., Ashmeade, Terri L., Miller, Elizabeth, and Gilbert, Jack A. Development of the preterm infant gut microbiome: A research priority. United States: N. p., 2014. Web. doi:10.1186/2049-2618-2-38.
Groer, Maureen W., Luciano, Angel A., Dishaw, Larry J., Ashmeade, Terri L., Miller, Elizabeth, & Gilbert, Jack A. Development of the preterm infant gut microbiome: A research priority. United States. doi:10.1186/2049-2618-2-38.
Groer, Maureen W., Luciano, Angel A., Dishaw, Larry J., Ashmeade, Terri L., Miller, Elizabeth, and Gilbert, Jack A. Mon . "Development of the preterm infant gut microbiome: A research priority". United States. doi:10.1186/2049-2618-2-38. https://www.osti.gov/servlets/purl/1225363.
@article{osti_1225363,
title = {Development of the preterm infant gut microbiome: A research priority},
author = {Groer, Maureen W. and Luciano, Angel A. and Dishaw, Larry J. and Ashmeade, Terri L. and Miller, Elizabeth and Gilbert, Jack A.},
abstractNote = {The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. In conclusion, the study speculates about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host.},
doi = {10.1186/2049-2618-2-38},
journal = {Microbiome},
issn = {2049-2618},
number = 1,
volume = 2,
place = {United States},
year = {2014},
month = {10}
}

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