Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose

Huang, Chen; Hao, Naijia; Bhagia, Samarthya; Li, Mi; Meng, Xianzhi; Pu, Yunqiao Joseph; Yong, Qiang; Ragauskas, Arthur J.

doi:10.1016/j.mtla.2018.09.008

Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose

Journal Article · Thu Sep 20 00:00:00 EDT 2018 · Materialia

DOI:https://doi.org/10.1016/j.mtla.2018.09.008· OSTI ID:1489096

Huang, Chen ^[1]; Hao, Naijia ^[2]; Bhagia, Samarthya ^[2]; ^[2]; Meng, Xianzhi ^[2]; ^[3]; Yong, Qiang ^[4]; ^[5]

Nanjing Forestry Univ., Nanjing (China); Univ. of Tennessee, Knoxville, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Nanjing Forestry Univ., Nanjing (China)
Univ. of Tennessee, Knoxville, TN (United States); Univ. of Tennessee Institute of Agriculture, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Research into artificial bone scaffolds has increased substantially over the past decade as current solutions have significant limitations. Inspired by mineral hydroxyapatite (HAP) in natural bone, this study developed a facile in situ HAP coating on cellulose nanocrystals (CNCs) matrix followed by a crosslinking reaction. By changing the amount of CNCs added to a simulated body fluid (SBF), HAP content in the nanocomposite could be controlled between 0 and 40.1%, with a HAP coating thickness of ~10 nm. Moreover, CNCs/HAP was crosslinked with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and polyethylene glycol (PEG) to enhance its water stability and mechanical properties. FTIR and NMR analysis revealed that crosslinking happened via an esterification reaction between CNCs, HAP, PMVEMA, and PEG. Compression strength of the scaffolds showed a result as high as 41.8 MPa, almost 20 times of scaffold prepared by just mixing CNCs and HAP. Further investigations revealed that this scaffold was highly porous (as high as 91.0%) and lightweight (with a density between 60-70 mg/cm³). In addition, this composite showed good biocompatibility as it can stabilize BSA protein, suggesting a promising material as a bone scaffold.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1489096

Journal Information:: Materialia, Journal Name: Materialia Journal Issue: C Vol. 4; ISSN 2589-1529

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Data for: Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose Ragauskas, Arthur https://doi.org/10.17632/sbrbsvthbm.1 The current record is supplemented by this dataset	dataset	January 2020
Data for: Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose Ragauskas, Arthur https://doi.org/10.17632/vzfgcg9pgc The current record is supplemented by this dataset	dataset	January 2020
Data for: Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose Ragauskas, Arthur https://doi.org/10.17632/vzfgcg9pgc.1 The current record is supplemented by this dataset	dataset	January 2020

Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose

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