skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose

Abstract

Research into artificial bone scaffolds has increased substantially over the past decade as current solutions have significant limitations. Inspired by mineral hydroxyapatite (HAP) in natural bone, this study developed a facile in situ HAP coating on cellulose nanocrystals (CNCs) matrix followed by a crosslinking reaction. By changing the amount of CNCs added to a simulated body fluid (SBF), HAP content in the nanocomposite could be controlled between 0 and 40.1%, with a HAP coating thickness of ~10 nm. Moreover, CNCs/HAP was crosslinked with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and polyethylene glycol (PEG) to enhance its water stability and mechanical properties. FTIR and NMR analysis revealed that crosslinking happened via an esterification reaction between CNCs, HAP, PMVEMA, and PEG. Compression strength of the scaffolds showed a result as high as 41.8 MPa, almost 20 times of scaffold prepared by just mixing CNCs and HAP. Further investigations revealed that this scaffold was highly porous (as high as 91.0%) and lightweight (with a density between 60-70 mg/cm 3). In addition, this composite showed good biocompatibility as it can stabilize BSA protein, suggesting a promising material as a bone scaffold.

Authors:
 [1];  [2];  [2]; ORCiD logo [2];  [2]; ORCiD logo [3];  [4]; ORCiD logo [5]
  1. Nanjing Forestry Univ., Nanjing (China); Univ. of Tennessee, Knoxville, TN (United States)
  2. Univ. of Tennessee, Knoxville, TN (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  4. Nanjing Forestry Univ., Nanjing (China)
  5. Univ. of Tennessee, Knoxville, TN (United States); Univ. of Tennessee Institute of Agriculture, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1489096
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Materialia
Additional Journal Information:
Journal Volume: 4; Journal Issue: C; Journal ID: ISSN 2589-1529
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Cellulose nanocrystals; Hydroxyapatite; Crosslinking; Strong mechanical property; Bone scaffold

Citation Formats

Huang, Chen, Hao, Naijia, Bhagia, Samarthya, Li, Mi, Meng, Xianzhi, Pu, Yunqiao Joseph, Yong, Qiang, and Ragauskas, Arthur J. Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose. United States: N. p., 2018. Web. doi:10.1016/j.mtla.2018.09.008.
Huang, Chen, Hao, Naijia, Bhagia, Samarthya, Li, Mi, Meng, Xianzhi, Pu, Yunqiao Joseph, Yong, Qiang, & Ragauskas, Arthur J. Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose. United States. doi:10.1016/j.mtla.2018.09.008.
Huang, Chen, Hao, Naijia, Bhagia, Samarthya, Li, Mi, Meng, Xianzhi, Pu, Yunqiao Joseph, Yong, Qiang, and Ragauskas, Arthur J. Thu . "Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose". United States. doi:10.1016/j.mtla.2018.09.008. https://www.osti.gov/servlets/purl/1489096.
@article{osti_1489096,
title = {Porous artificial bone scaffold synthesized from a facile in situ hydroxyapatite coating and crosslinking reaction of crystalline nanocellulose},
author = {Huang, Chen and Hao, Naijia and Bhagia, Samarthya and Li, Mi and Meng, Xianzhi and Pu, Yunqiao Joseph and Yong, Qiang and Ragauskas, Arthur J.},
abstractNote = {Research into artificial bone scaffolds has increased substantially over the past decade as current solutions have significant limitations. Inspired by mineral hydroxyapatite (HAP) in natural bone, this study developed a facile in situ HAP coating on cellulose nanocrystals (CNCs) matrix followed by a crosslinking reaction. By changing the amount of CNCs added to a simulated body fluid (SBF), HAP content in the nanocomposite could be controlled between 0 and 40.1%, with a HAP coating thickness of ~10 nm. Moreover, CNCs/HAP was crosslinked with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and polyethylene glycol (PEG) to enhance its water stability and mechanical properties. FTIR and NMR analysis revealed that crosslinking happened via an esterification reaction between CNCs, HAP, PMVEMA, and PEG. Compression strength of the scaffolds showed a result as high as 41.8 MPa, almost 20 times of scaffold prepared by just mixing CNCs and HAP. Further investigations revealed that this scaffold was highly porous (as high as 91.0%) and lightweight (with a density between 60-70 mg/cm3). In addition, this composite showed good biocompatibility as it can stabilize BSA protein, suggesting a promising material as a bone scaffold.},
doi = {10.1016/j.mtla.2018.09.008},
journal = {Materialia},
issn = {2589-1529},
number = C,
volume = 4,
place = {United States},
year = {2018},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Save / Share: