Bio-inspired nanocomposite by layer-by-layer coating of chitosan/hyaluronic acid multilayers on a hard nanocellulose-hydroxyapatite matrix
- Chinese Academy of Forestry, Nanjing (China); Nanjing Forestry Univ. (China); Univ. of Tennessee, Knoxville, TN (United States)
- Chinese Academy of Forestry, Nanjing (China)
- Univ. of Tennessee, Knoxville, TN (United States)
- Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Nanjing Forestry Univ. (China)
We report on a layer-by-layer technique on the hard CNCs/hydroxyapatite (HAP) matrix using biodegradable and biocompatible chitosan and hyaluronic acid (HA). Inspired by the mineralized collagen in human bone, the CNCs/HAP matrix was synthesized by a facile in situ HAP coating on the CNCs fibers. The chemical and crystalline structure of the CNCs/HAP matrix was investigated with FTIR, XRD, HRTEM, and SAED. The surface of the CNCs/HAP matrix was analyzed by AFM which showed a flat structure with a roughness of 23.12 nm, however, the surface roughness increased to 56.09 nm with the assembly of chitosan and HA. After the LBL assembly, the surface hydrophilicity of the CNCs/HAP films was improved. Furthermore, the CNCs/HAP matrix showed enhanced mechanical property than pure CNCs matrix. Although there is compromise in the mechanical property after the LBL assembly, it is anticipated its bioaffinity and biocompatibility will increase with the incoporation of chitosan and HA.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC05-00OR22725
- OSTI ID:
- 1545199
- Journal Information:
- Carbohydrate Polymers, Vol. 222, Issue C; ISSN 0144-8617
- Publisher:
- Applied Science DirectCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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