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Title: Bio-inspired nanocomposite by layer-by-layer coating of chitosan/hyaluronic acid multilayers on a hard nanocellulose-hydroxyapatite matrix

Journal Article · · Carbohydrate Polymers
 [1];  [2];  [3]; ORCiD logo [4];  [3];  [5]; ORCiD logo [4]
  1. Chinese Academy of Forestry, Nanjing (China); Nanjing Forestry Univ. (China); Univ. of Tennessee, Knoxville, TN (United States)
  2. Chinese Academy of Forestry, Nanjing (China)
  3. Univ. of Tennessee, Knoxville, TN (United States)
  4. Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  5. Nanjing Forestry Univ. (China)
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We report on a layer-by-layer technique on the hard CNCs/hydroxyapatite (HAP) matrix using biodegradable and biocompatible chitosan and hyaluronic acid (HA). Inspired by the mineralized collagen in human bone, the CNCs/HAP matrix was synthesized by a facile in situ HAP coating on the CNCs fibers. The chemical and crystalline structure of the CNCs/HAP matrix was investigated with FTIR, XRD, HRTEM, and SAED. The surface of the CNCs/HAP matrix was analyzed by AFM which showed a flat structure with a roughness of 23.12 nm, however, the surface roughness increased to 56.09 nm with the assembly of chitosan and HA. After the LBL assembly, the surface hydrophilicity of the CNCs/HAP films was improved. Furthermore, the CNCs/HAP matrix showed enhanced mechanical property than pure CNCs matrix. Although there is compromise in the mechanical property after the LBL assembly, it is anticipated its bioaffinity and biocompatibility will increase with the incoporation of chitosan and HA.

Research Organization:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1545199
Journal Information:
Carbohydrate Polymers, Vol. 222, Issue C; ISSN 0144-8617
Publisher:
Applied Science DirectCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 24 works
Citation information provided by
Web of Science

Figures / Tables (7)

Fig. 1(p. 10)figure Fig. 1
Fig. 2(p. 12)figure Fig. 2
Fig. 3(p. 15)figure Fig. 3
Fig. 4(p. 16)figure Fig. 4
Fig. 5(p. 18)figure Fig. 5
Fig. 6(p. 19)figure Fig. 6
Table 1(p. 20)table Table 1

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Related Subjects

36 MATERIALS SCIENCE
CNCs/HAP matrix
LBL assembly
Chitosan
Hyaluronic acid