Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals

Huang, Chen; Bhagia, Samarthya; Hao, Naijia; Meng, Xianzhi; Liang, Luna; Yong, Qiang; Ragauskas, Arthur J.

doi:10.1039/c8ra09523j

Title: Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals

Journal Article · Fri Feb 15 00:00:00 EST 2019 · RSC Advances

DOI:https://doi.org/10.1039/c8ra09523j· OSTI ID:1507845

Huang, Chen ^[1];

^[2]; Hao, Naijia ^[3];

^[3]; Liang, Luna ^[3];

^[4];

^[2]

Nanjing Forestry Univ., Nanjing (China); Univ. of Tennessee, Knoxville, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States)
Nanjing Forestry Univ., Nanjing (China)

A novel nanocomposite scaffold was developed by homogeneous deposition of hydroxyapatite (HAP) on a cellulose nanocrystals (CNCs) matrix suspended in a simulated body fluid (SBF). By adjusting the pH of the SBF, the HAP content in the nanocomposite could be controlled between 15 wt% and 47 wt%. Physical and chemical characteristics of the nanocomposites were analyzed by SEM, FTIR, XRD, SAED, and TEM, which confirmed the successful incorporation of HAP onto the CNCs. The nanocomposites were then freeze-casted into porous scaffolds by different solidification technologies (i.e., directional freezing (DF), plunging in liquid N₂ (PL) or in a -20 °C freezer (FZ)) followed by lyophilization. Compression testing of the HAP/CNCs foams indicated that DF caused significant improvement in mechanical properties due to the specific orientation and anisotropic porous structure compared to conventional freezing methods such as PL and FZ. Moreover, the scaffold with high HAP content exhibited improved mechanical and thermal properties, which holds potential for application in bone tissue engineering.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD); Doctorate Fellowship Foundation of Nanjing Forestry Univ.

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1507845

Journal Information:: RSC Advances, Vol. 9, Issue 10; ISSN 2046-2069

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 25 works

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