Biological imaging by soft x-ray diffraction microscopy

Shapiro, D.; Thibault, P.; Beetz, T.; Elser, V.; Howells, M.; Jacobsen, C.; Kirz, J.; Lima, E.; Miao, H.; Neiman, A. M.; Sayre, D.

doi:10.1073/pnas.0503305102

Biological imaging by soft x-ray diffraction microscopy

Journal Article · Tue Oct 25 00:00:00 EDT 2005 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.0503305102· OSTI ID:1164139

Shapiro, D. ^[1]; Thibault, P. ^[2]; Beetz, T. ^[3]; Elser, V. ^[2]; Howells, M. ^[4]; Jacobsen, C. ^[3]; Kirz, J. ^[5]; Lima, E. ^[6]; Miao, H. ^[6]; Neiman, A. M. ^[7]; Sayre, D. ^[6]

Stony Brook Univ., Stony Brook, NY (United States); Argonne National Laboratory
Cornell Univ., Ithaca, NY (United States)
Stony Brook Univ., Stony Brook, NY (United States); Brookhaven National Lab., Upton, NY (United States). Center for Functional Nanomaterials
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source
Stony Brook Univ., Stony Brook, NY (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source
Stony Brook Univ., Stony Brook, NY (United States)
State Univ. of New York at Stony Brook, NY (United States)

We have used the method of x-ray diffraction microscopy to image the complex-valued exit wave of an intact and unstained yeast cell. The images of the freeze-dried cell, obtained by using 750-eV x-rays from different angular orientations, portray several of the cell's major internal components to 30-nm resolution. The good agreement among the independently recovered structures demonstrates the accuracy of the imaging technique. To obtain the best possible reconstructions, we have implemented procedures for handling noisy and incomplete diffraction data, and we propose a method for determining the reconstructed resolution. This work represents a previously uncharacterized application of x-ray diffraction microscopy to a specimen of this complexity and provides confidence in the feasibility of the ultimate goal of imaging biological specimens at 10-nm resolution in three dimensions.

View Accepted Manuscript (DOE)

Research Organization:: Stony Brook Univ., Stony Brook, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: FG02-04ER46128

OSTI ID:: 1164139

Alternate ID(s):: OSTI ID: 913688

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 43 Vol. 102; ISSN 0027-8424

Publisher:: National Academy of Sciences, Washington, DC (United States)Copyright Statement

Country of Publication:: United States

Language:: English

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