[Bifunctional chelates of Rh-105, Au-199, and other metallic radionuclides as potential radiotherapeutic agents]

Technical Report · Tue Dec 31 04:00:00 EST 1991

DOI:https://doi.org/10.2172/10187279· OSTI ID:10187279

Progress during this period is reported under the following headings: Diethylenetriamine based and related bifunctional chelating agents and their complexation with Rh-105, Au-198, Pd-109, cu-67, In-111, and Co-57; studies of Pd-109, Rh-105 and Tc-99m with bifunctional chelates based on phenylenediamine; establishment of an appropriate protein assay method for conjugated proteins; studies of new bifunctional Bi, Tri and tetradentate amine oxime ligands with Rh-105; IgG and antibody B72.3 conjugation studies by HPLC Techniques with bifunctional metal chelates; and progress on ligand systems for Au(III).

• Research Organization: Missouri Univ., Columbia, MO (United States). Dept. of Chemistry
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-86ER60400
• OSTI ID: 10187279
• Report Number(s): DOE/ER/60400--6; ON: DE93003146
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400202
550604
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
CHELATING AGENTS
COPPER 67
GOLD 199
INDIUM 111
ISOTOPE EFFECTS, ISOTOPE EXCHANGE, AND ISOTOPE SEPARATION
LABELLING
LIGANDS
PALLADIUM 109
PHENOLS
PORPHYRINS
RADIOPHARMACEUTICALS
RUTHENIUM 105
STRUCTURE-ACTIVITY RELATIONSHIPS
UNSEALED RADIONUCLIDES IN THERAPY