Bifunctional chelates of Rh-105 and Au-199 as potential radiotherapeutic agents

Technical Report · Wed Jan 24 23:00:00 EST 1990

DOI:https://doi.org/10.2172/7170301· OSTI ID:7170301

Troutner, D E; Schlemper, E O

Since last year we have: continued the synthesis of pentadentate bifunctional chelating agents based on diethylene triamine; studied the chelation Rh-105, Au-198 (as model for Au-199) and Tc-99m with these agents as well as chelation of Pd-109, Cu-67, In-111, and Co-57 with some of them; synthesized a new class of potential bifunctional chelating agents based on phenylene diamine; investigated the behavior of Au-198 as a model for Au-199; begun synthesis of bifunctional chelating agents based on terpyridly and similar ligands; and continued attempts to produce tetradentate bifunctional chelates based on diaminopropane. Each of these will be addressed in this report.

• Research Organization: Missouri Univ., Columbia, MO (USA). Dept. of Chemistry
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-86ER60400
• OSTI ID: 7170301
• Report Number(s): DOE/ER/60400-4; ON: DE90009963
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
CHELATES
CHELATING AGENTS
CHEMICAL PREPARATION
COBALT COMPLEXES
COMPLEXES
COPPER COMPLEXES
DOCUMENT TYPES
GOLD COMPLEXES
INDIUM COMPLEXES
ISOTOPES
LIGANDS
MEDICINE
MOLECULAR STRUCTURE
NUCLEAR MEDICINE
PALLADIUM COMPLEXES
PROGRESS REPORT
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RHODIUM COMPLEXES
SYNTHESIS
TECHNETIUM COMPLEXES
THERAPY
TRANSITION ELEMENT COMPLEXES