Bifunctional chelates of Rh-105 and Au-199 as potential radiotherapeutic agents

Technical Report · Thu Jan 24 23:00:00 EST 1991

OSTI ID:721055

Schlemper, E O; Ketring, A R

Progress on this research includes: studied complexation of Pd-109 and Rh-105 with two bifunctional chelating agents based on phenylenediamine and studied the coupling of these to proteins; established an appropriate protein assay method for our needs with our conjugated proteins; developed a new bifunctional tetradentate ligand based on 1,3-diaminopropane and studied it complexation with Rh-105; studied conjugation of IgG and antibody B72.3 with Tc-99m and Rh-105 by HPLC techniques using the new ligand above and the functionalized pentadentate ligand system developed last year; continued development of terpyridyl and dipicoyl amine related bifunctional ligands primarily for Au-3 application; and began the development of substituted porphyrin ligands for primarily Au-3 application. 10 refs., 17 figs., 8 tabs.

• Research Organization: Missouri Univ., Columbia, MO (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: FG02-86ER60400
• OSTI ID: 721055
• Report Number(s): DOE/ER/60400--5; ON: TI91020427
• Country of Publication: United States
• Language: English

Related Subjects

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BIOASSAY
BUFFERS
CHELATES
CHELATING AGENTS
CHEMICAL REACTION YIELD
COPPER 67
GOLD 199
LABELLED COMPOUNDS
LABELLING
LIGANDS
LIQUID COLUMN CHROMATOGRAPHY
MOLECULAR STRUCTURE
MONOCLONAL ANTIBODIES
PALLADIUM 109
PROGRESS REPORT
PROTEINS
RADIOPHARMACEUTICALS
RADIOTHERAPY
RHODIUM 105
SYNTHESIS
TECHNETIUM 99
THERAPEUTIC USES